BEIJING, CHINA — Decades after their initial discovery in northern China, a skull fragment and a jaw fragment unearthed at the Xujiayao archaeological site have been officially identified as belonging to Denisovans, an elusive sister group to Neanderthals. The breakthrough finding, published in the journal Nature, bridges a significant gap in paleoanthropology by shedding new light on what these enigmatic ancient humans looked like and where they roamed.

The research was led by Qiaomei Fu of the Chinese Academy of Sciences, alongside an international team of colleagues who applied cutting-edge biomolecular and digital imaging techniques to ancient skeletal remains originally excavated in the 1970s. For generations, anthropologists and paleoanthropologists have grappled with the classification of the Xujiayao hominin fossils, struggling to place them definitively within the complex and rapidly evolving human family tree. The new study relies on a combination of ancient protein analysis and advanced three-dimensional modeling to resolve this long-standing debate.
To make the identification, Fu and her research team successfully extracted and analyzed 18 proteins preserved within the ancient fossils. Among these biomolecules, the researchers isolated a specific collagen variant that serves as a molecular fingerprint. Crucially, this particular collagen variant is found exclusively in Denisovans and is entirely absent in Neanderthals as well as modern humans (Homo sapiens). This biochemical marker provided the definitive clue that the Xujiayao fragments belonged to the Denisovan lineage.

Following the molecular identification, the team shifted their focus to the physical morphology of the bones. Researchers evaluated the anatomical shapes of the skull and jaw fragments, employing sophisticated 3D computer models to digitally reconstruct the missing portions of the bones. These virtual reconstructions allowed the team to perform comparative anatomical analyses, matching the Xujiayao digital models against an extensive database of fossilized remains belonging to Neanderthals, modern humans, and various other archaic hominin species.
The resulting analysis offers the clearest picture yet of Denisovan anatomy. According to the study, Denisovan physical traits represented a unique mosaic, combining characteristics derived from ancestral hominins, Neanderthals, and other later human species. Specifically, the researchers concluded that Denisovans possessed low, relatively flat skulls characterized by unusually thick cranial bones, prominent brow ridges, and flattened facial features.

This distinctive blend of primitive and specialized features has profound implications for how scientists view human evolution across Asia. Because the Xujiayao site is located in northern China, the researchers point out that Denisovans likely inhabited a vast geographic range spanning across East Asia. Consequently, the team suggests that several other previously discovered, unclassified hominin fossils from the same region may also belong to this sprawling Denisovan lineage, urging a re-evaluation of museum collections and archaeological archives throughout the continent.
The discovery reinforces the growing scientific consensus that Asia was a critical crucible for human evolution, populated by diverse archaic human groups that interacted, interbred, and contributed genetic material to modern human populations. While Denisovans were first identified through DNA extracted from a tiny finger bone found in Denisova Cave in Siberia’s Altai Mountains, this new research demonstrates that Denisovan presence extended far to the south and east, leaving a distinct anatomical and molecular footprint in what is now China.

As researchers continue to refine techniques in paleoproteomics—the study of ancient proteins—and digital morphological reconstruction, archaeologists anticipate that more long-forgotten fossils housed in regional museums will yield secrets about our ancient relatives. For now, the re-examination of the Xujiayao fragments marks a major milestone in understanding the true diversity, appearance, and distribution of one of humanity’s closest evolutionary cousins.